ISSN 2398-2950      

Natriuretic peptides

ffelis

Synonym(s): NP


Introduction

  • The natriuretic peptides are a group of structurally related but genetically distinct peptides that induce vasodilation and natriuresis.
  • NPs are released in response to physiological and pathological stimulation, including:
    • Exercise.
    • Hypoxia.
    • Ischemia.
    • Sepsis Shock: septic.
    • Increased cardiac wall stress.
    • Chamber dilatation/stretch.
  • Although atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been extensively studied, C-type natriuretic peptide (CNP) and dendroaspis natriuretic peptide (DNP) have also been identified.

Pathophysiology

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Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)

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Elimination and measurement

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Use of NP assays

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Oyama M A, Boswood A, Connolly D J et al (2013) Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease. JAVMA 243 (1), 71-82 PubMed.
  • Singletary G E, Rush J E, Fox P R et al (2012) Effect of NT-pro-BNP assay on accuracy and confidence of general practitioners in diagnosing heart failure or respiratory disease in cats with respiratory signs. JVIM 26 (3), 542-546 PubMed.
  • Fox P R, Rush J E, Reynolds C A et al (2011) Multicenter evaluation of plasma N-terminal probrain natriuretic peptide (NT-proBNP) as a biochemical screening test for asymptomatic (occult) cardiomyopathy in cats. JVIM 25 (5), 1010-1016 PubMed.
  • Wess G, Daisenberger P, Mahling M et al (2011) Utility of measuring plasma N-terminal pro-brain natriuretic peptide in detecting hypertrophic cardiomyopathy and differentiating grades of severity in cats. Vet Clin Pathol 40 (2), 237-244 PubMed.
  • Connolly D J (2010) Natriuretic peptides: the feline experience. Vet Clin North Am Small Anim Pract 40 (4), 559-570 PubMed.
  • Lalor S M, Connolly D J, Elliott J et al (2009) Plasma concentrations of natriuretic peptides in normal cats and normotensive and hypertensive cats with chronic kidney disease. J Vet Cardiol 11 (Suppl 1), S71-79 PubMed.

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