Felis ISSN 2398-2950

Mast cell tumor: chemotherapy protocols

Contributor(s): Jane Dobson, Corey Saba, Isabelle Desmas-Bazelle

Introduction

  • The following chemotherapy protocols for mast cell tumors will be covered:
    • Protocol 1: Vinblastine/prednisolone protocol.
    • Protocol 2: CCNU + prednisolone.
    • Protocol 3: Tyrosine kinase inhibitors (TKI). 

Protocols are not listed in order of preference or efficacy.Do not use without consulting specialist oncologist.Refer to chemotherapy safety administration Chemotherapy: safe handling.

Protocol 1

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Protocol 2

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Protocol 3

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Legal and safety precautions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Berger E P, Johannes C M, Post G S, Rothchild G, Shiu K B, Wetzel S, Fox L E (2018) Retrospective evaluation of toceranib phosphate (Palladia) use in cats with mast cell neoplasia. J Feline Med Surg 20(2), 95-102 PubMed.
  • Harper A, Blackwood L (2017) Toxicity and response in cats with neoplasia treated with toceranib phosphate. J Feline Med Surg 19 (6), 619-623 PubMed.
  • Musser M L, Quinn H T, Chretin J D (2012) Low apparent risk of CCNU (lomustine)-associated clinical hepatotoxicity in cats. J Feline Med Surg 14(12), 871-875 PubMed.
  • Rassnick K M, Williams L E, Kristal O et al (2008) Lomustine for treatment of mast cell tumors in cats: 38 cases (1999-2005). J Am Vet Med Assoc 232 (8), 1200-1205 PubMed.
  • Lachowicz  J L, Post G S, Brodsky E (2005) A Phase I Clinical Trial Evaluating Imatinib Mesylate (Gleevec) in Tumor‐Bearing Cats. J Vet Intern Med 19 (6), 860-864 PubMed.
  • Graham-Mize C A,  Rosser E  J (2004) Bioavailability and activity of
    prednisone and prednisolone in the feline patient.
    Vet Dermatol 15 (Suppl 1), 9-10.
  • Fan T M, Kitchell B E, Dhaliwal R S et al (2002) Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats: critical assessment of a practical dosing regimen. J Am Anim Hosp Assoc 38 (4), 357-363 PubMed.
  • Rassnick K M, Gieger T L, Williams L E et al (2001) Phase I evaluation of CCNU (lomustine) in tumor-bearing cats. J Vet Intern Med 15 (3), 196-199 PubMed.
  • Rassnick K M, Moore A S, Williams L E et al (1999) Treatment of mast cell tumors with CCNU (lomustine). J Vet Intern Med 13 (6), 601-605 PubMed.


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