Felis ISSN 2398-2950

Lymphoma: chemotherapy protocols

Synonym(s): Immediate to high grade lymphoma chemotherapy protocols

Contributor(s): Corey Saba, Isabelle Desmas-Bazelle

Introduction

  • The following chemotherapy protocols for lymphoma will be covered:
    • Induction protocols:
      • Modified UW-Madison (UW 25) (CHOP-based).
      • Combination cytotoxic therapy COP.
    • Rescue protocols:
      • CCNU + prednisolone.
      • Doxorubicin + prednisolone.
Do not use without consulting specialist oncologist.Refer to chemotherapy safety administration Chemotherapy: safe handling.

Induction protocols

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Protocol 2: Combination cytotoxic therapy COP

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Rescue protocols

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Legal and safety precautions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Elliott J, Finotello R (2018) A dexamethasone, melphalan, actinomycin‐D and cytarabine chemotherapy protocol as a rescue treatment for feline lymphoma. Vet Comp Oncol 16 (1), E144-E151 PubMed.
  • Martin O A, Price J (2018) Mechlorethamine, vincristine, melphalan and prednisolone rescue chemotherapy protocol for resistant feline lymphoma. J Feline Med Surg 20(10), 934-939 PubMed.
  • Collette S A, Allstadt S D, Chon E M, Vernau W, Smith A N, Garrett L D, Choy K, Rebhun R B, Rodriguez C O, Skorupski K A (2016) Treatment of feline intermediate‐ to high‐grade lymphoma with a modified university of Wisconsin–Madison protocol: 119 cases (2004–2012). Vet Comp Oncol 14 (1), 136-146 PubMed.
  • Krick E L, Cohen R B, Gregor T P, Salah P C, Sorenmo K U (2013) Prospective Clinical Trial to Compare Vincristine and Vinblastine in a COP ‐Based Protocol for Lymphoma in Cats. J Vet Intern Med 27(1), 134-140 PubMed.
  • Waite A H K, Jackson K, Gregor T P, Krick E L (2013) Lymphoma in cats treated with a weekly cyclophosphamide-, vincristine-, and prednisone-based protocol: 114 cases (1998–2008). J Am Vet Med Assoc 242(8), 1104-1109 PubMed.  
  • Dutelle A L, Bulman-Fleming J C, Lewis C A, Rosenberg M P (2012) Evaluation of lomustine as a rescue agent for cats with resistant lymphoma. J Feline Med Surg 14 (10), 694-700 PubMed.
  • Oberthaler K T, Mauldin E, McManus P M, Shofer S, Sorenmo K U (2009) Rescue therapy with doxorubicin-based chemotherapy for relapsing or refractory feline lymphoma: A retrospective study of 23 cases. J Feline Med Surg 11(4), 259-265 PubMed.
  • Milner R J, Peyton J, Cooke K et al (2005) Response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol: 38 cases (1996-2003). JAVMA 227 (7), 1118-1122 PubMed.
  • Brønden L B, Rutteman G R, Flagstad A et al (2003) Study of dog and cat owners' perceptions of medical treatment for cancer. Vet Rec 152 (3), 77-80 PubMed.
  • Fan T M, Kitchell B E, Dhaliwal R S et al (2002) Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats: critical assessment of a practical dosing regimen. JAAHA 38 (4), 357-363 PubMed.
  • Teske E, van Straten G, van Noort R et al (2002) Chemotherapy with cyclophoshamide, vincristine, and prednisolone (COP) in cats with malignant lymphoma: new results with an old protocol. J Vet Intern Med 16 (2), 179-86 PubMed.
  • Guillermo Couto C (2001) What is new on feline lymphoma? J Feline Med Surg (4), 171-176 PubMed.
  • Kristal O, Lana S E, Ogilvie G K, Rand W M, Cotter S M, Moore A S (2001) Single Agent Chemotherapy with Doxorubicin for Feline Lymphoma: A Retrospective Study of 19 Cases (1994–1997). J Vet Intern Med 15 (2), 125-130 PubMed.
  • Malik R, Gabor L J, Foster S F et al (2001) Therapy for Australian cats with lymphosarcoma. Aust Vet J 79 (12), 808-817 PubMed.
  • Rassnick K M, Gieger T L, Williams L E et al (2001) Phase 1 evaluation of CCNU (lomustine) in tumor-bearing cats. J Vet Intern Med 15 (3), 196-199 PubMed.
  • Zwahlen C H, Lucroy M D, Kraegel S A et al (1998) Results of chemotherapy for cats with alimentary malignant lymphoma: 21 cases (1993-1997). JAVMA 213 (8), 1144-1149 PubMed.
  • Moore A S, Cotter S M, Frimberger A E et al (1996) A comparison of doxorubicin and COP for maintenance of remission in cats with lymphoma. J Vet Intern Med 10 (6), 372-375 PubMed.

Other sources of information

  • Vail D M, Pinkerton M E (2020) Feline lymphoma and leukemias. In: Small Animal Clinical Oncology. 6th edn. Eds Withrow & MacEwen’s. Elsevier Saunders, St. Louis. pp 715-729. 
  • Morrison W B (2002) Cancer in Dogs and Cats. 2nd edition, p 662.
  • Tennant B (2002) BSAVA Small Animal Formulary, 4th edn. pp 280-281.


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