ISSN 2398-2950      

Allergen-specific immunotherapy

ffelis

Synonym(s): ASIT, hyposensitization


Introduction

  • Allergen-specific immunotherapy is suggested to alter the immune response to allergens and, as such, other than allergen avoidance, it is theoretically the best treatment for atopic dermatitis Skin: atopy as it treats the primary condition itself.
    • It changes a Th2 response to a Th1 response with altered cytokine expression.
    • It induces activity of T-reg cells which express suppressive cytokines.
    • IgG production increases which may capture antigen that might otherwise cause allergic reactions.

When to recommend ASIT

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Types of immunotherapy

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Side-effects of immunotherapy

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Concurrent use with anti-inflammatory treatment

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • DeBoer D J, Verbrugge M, Morris M (2016) Clinical and immunological responses of dust mite sensitive, atopic dogs to treatment with sublingual immunotherapy (SLIT). Vet Dermatol 27 (2), 82-7e23 PubMed.
  • Olivry T, DeBoer D J, Favrot C et al (2015) Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Vet Res 11, 210 PubMed.
  • Willemse A, Van den Brom W E, Rijnberk A (1984) Effect of hyposensitization on atopic dermatitis in dogs. JAVMA 184 (10), 1277-1280 PubMed.

Other sources of information

  • Favrot C (2017) What is new in allergen-specific immunotherapy? In: Proceedings of 29th Annual ESVD-ECVD Congress, Lausanne.
  • Miller W H, Griffin C E & Campbell K L (2013) Hypersensitivity disorders – allergen-specific immunotherapy. In: Muller & Kirk’s Small Animal Dermatology. 7th edn. Elsevier Inc, Missouri,  pp 383.

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