Felis ISSN 2398-2950

Squamous cell carcinoma

Synonym(s): Epidermoid carcinoma

Contributor(s): William Brewer Jr, Irene Rochlitz, David Scarff

Introduction

  • A common, malignant neoplastic disorder.
  • Often on the ears, nose or lower eyelid of white cats Squamous cell carcinoma: pinna 04 - recurrence .
  • Cause: actinic keratosis may precede.
  • Signs: erosive or ulcerative lesions typically of nasal planum or ear tips but may affect other sites and can manifest as a proliferative mass.
  • Diagnosis: histopathology.
  • Treatment: surgical resection or radiotherapy are most effective treatments. Preliminary studies utilizing photodynamic therapy on intralesional chemotherapy are promising.
  • Prognosis: fair- locally invasive but slow to metastasize.

Pathogenesis

Etiology

  • UV damage   →   actinic keratosis = premalignant lesion   →   invasive squamous cell carcinoma.
  • Rarely arises at site of previous burn injury.
  • Rare sequela to eosinophilic ulcer Eosinophilic granuloma complex on lip.

Predisposing factors

General

  • Light or non-pigmented skin.
  • White cats are 13 times overrepresented.

Pathophysiology

  • Ultraviolet (UV) damage to unpigmented skin.
  • Malignant transformation of keratinocytes.

Timecourse

  • Months to years.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Rees C A, Goldschmidt M H (1998) Cutaneous horn and squamous cell carcinoma in situ (Bowen's disease) in a cat. JAAHA 34 (6) 485-486 PubMed.
  • Lana S E, Ogilvie G K, Withrow S J et al (1997) Feline cutaneous squamous cell carcinoma of the nasal planum and the pinnae - 61 cases. JAAHA 33 (4), 329-332 PubMed.

Other sources of information

  • Fox L E (1995) Feline Cutaneous and Subcutaneous Neoplasms. Veterinary Clinics North America: Small Animal Practice pp 961-979.


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