Felis ISSN 2398-2950

Skin: pemphigus erythematosus

Contributor(s): Prof Douglass Macintire, David Scarff, Richard Squires

Introduction

  • Extremely rare immune-mediated disease in cats.
  • Has some features of pemphigus foliaceus Skin: pemphigus foliaceus and systemic lupus erythematosus  Systemic lupus erythematosus but is often less aggressive.
  • Signs: erythematous, pustular dermatitis usually affecting face ( periocular, junction of nasal planum to haired skin, occasionally lip margins) .
  • Diagnosis: biopsy and immunohistopathology.
  • Treatment: immunosuppressive therapy.
  • Prognosis: reasonable.
    Print off the owner factsheet on Pemphigus  Pemphigus  to give to your client.

Pathogenesis

Etiology

  • Unknown.

Pathophysiology

  • Autoantibodies directed against intercellular cement substance and/or keratinocyte cell membrane cause damage and loss of cohesion which   →   skin lesions.
  • See also other forms of pemphigus:
  • Immunoglobulin with or without complement is deposited in intracellular spaces and/or basement zone.
  • Autoantibody against intercellular cement of epidermis   →  acantholysis (loss of cohesion between epidermal cells) and blister formation.
  • Intragranular or subcorneal acantholysis.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ackerman L J (1985) Canine and feline pemphigus and pemphigoid. Part I. Pemphigus. Comp Cont Educ Pract Vet (2), 89-97 VetMedResource.
  • Faircloth J C & Montgomery J K Jr. (1982) Pemphigus erythematosus in a cat. Feline Prac 12 (5), 31-33 VetMedResource.
  • Manning T O, Scott D W, Smith C A et al (1982) Pemphigus diseases in the feline; seven cases reports and discussion. JAAHA 18 (3), 433-443 VetMedResource.
  • Scott D W, Miller W H Jr., Lewis R M et al (1980) Pemphigus erythematosus in the dog and cat. JAAHA 16 (6), 815-823 VetMedResource.


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