Felis ISSN 2398-2950

Skin: panniculitis

Synonym(s): Nodular panniculitis, necrotizing steatitis

Contributor(s): David Godfrey

Introduction

  • Cause: inflammation of subcutaneous fat.
  • Signs: sinus tracts, nodules and fistulae.
  • Diagnosis: history, signs, histopathology.
  • Treatment: surgery, antibiosis, immunosuppressive glucocorticoids, Vitamin E.
  • Prognosis: varies according to cause.

Pathogenesis

Etiology

Nutritional

  • Relative or absolute vitamin E deficiency (due to diet rich in oily fish, eg tuna).

Predisposing factors

General

  • May develop after subcutaneous injection.

Pathophysiology

  • Inflammation of subcutaneous fat.
  • Damage to fat cells releases lipid into extracellular space.
  • Lipid is converted to fatty acids and these are potent inflammation inducers.
  • Granulomatous reactions to fatty acids develop.
  • Can be sterile or infectious.

Timecourse

  • Weeks.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Alander-Damsten Y K, Brander E E & Paulin L G (2003) Panniculitis, due to Mycobacterium smegmatis, in two Finnish cats. J Feline Med Surg (1), 19-26 PubMed.
  • Scott D W & Anderson W I (1988) Panniculitis in dogs and cats - a retrospective study of 78 cases. JAAHA 24 (5), 551-9 VetMedResource.


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