Felis ISSN 2398-2950

Skin: lymphocytic neoplasia

Synonym(s): Lymphosarcoma, lymphoma, mycosis fungoides, Sezary syndrome

Contributor(s): William Brewer Jr, David Scarff, Irene Rochlitz

Introduction

  • Uncommon, malignant lymphoid proliferations in dermis, sometimes with epitheliotropism.
  • Early stages may appear inflammatory, plaque-like or alopecic.
  • Later, nodular, sometimes oral.

Pathogenesis

Etiology

Pathophysiology

  • Primary cutaneous lymphosarcoma originates in the skin.
  • Secondary cutaneous lymphosarcoma arises by dissemination from another site .
  • Primary cutaneous lymphosarcoma includes:

Non-epitheliotropic lymphosarcoma

  • A tumor of B-lymphocytes or T-lymphocytes, causing generalized, multifocal or occasionally solitary dermal or subcutaneous nodules.

Epitheliotropic lymphosarcoma

  • Very rare tumor of T-lymphocytes includes:
    • Mycosis fungoides (a primary cutaneous lymphoma).
    • Sezary syndrome (a leukemic variant of mycosis fungoides).

Timecourse

  • Weeks to months.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Tobey J C, Houston D M, Breur G J et al (1994) Cutaneous T-cell lymphoma in a cat. JAVMA 204 (4), 606-9 PubMed.
  • Schick R O, Murphy G F, Goldschmidt M H (1993) Cutaneous lymphosarcoma and leukaemia in a cat. JAVMA 203 (8), 1155-58 VetMedResource.
  • Wellman M  L, Hammer A S, DiBartola S P et al (1992) Lymphoma involving large granular lymphocytes in cats - 11 cases (1982-1991). JAVMA 201 (8), 1265-9 PubMed.


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