Felis ISSN 2398-2950

Retina: degeneration (FPRD/FCRD comparison)

Synonym(s): Feline central retinal degeneration (FCRD), Feline progressive retinal degeneration (FPRD)

Contributor(s): Dennis E Brooks, Grant Roxburgh, David Williams

Introduction

  • Inherited retinal degeneration seen in Abyssinian; early and late form generalized retinal degeneration, late-onset suspected in Siamese Retina: inherited degenerations.
  • Also seen in some Domestic Shorthaired cats, etiology unknown.
  • Feline Central Retinal Degeneration (FCRD) associated with taurine deficiency Taurine deficiency.
  • Signs: visual deficit especially at night, nervousness with other animals, may be no obvious clinical signs, pupil dilation and increased tapetal reflex visible through pupil.
  • Diagnosis: ophthalmic examination, electroretinography, blood taurine assay.
  • Treatment: dependent on cause.
  • Prognosis: most degenerations are progressive unless predisposing factors can be treated. Pet cats usually cope well with blindness.

Pathogenesis

Etiology

FCRD

  • Associated with a poor diet containing insufficient taurine Taurine deficiency. Often owner is feeding cat an improvised diet or dog food.

FPRD

  • In the early onset inherited retinal degenerations, there is a suggestion that poor dark regulation of cGMP phosphodiesterase may be responsible.

Pathophysiology

FPRD

  • Not well understood.

FCRD

  • Taurine postulated to act as a neurotransmitter, may have cell membrane protective effect.

Timecourse

  • Usually chronic for both FCRD and FPRD.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Millichamp N J (1990) Retinal degeneration in the dog and cat. Vet Clin NA Small Anim Pract 20 (3), 799-835 PubMed.
  • Narfström K (1985) Progressive retinal atrophy in the Abyssinian cat - clinical characteristics. Invest Ophthalmol Vis Sci 26 (2), 193-200 PubMed.

Other sources of information

  • Nasisse M P (1991) Feline ophthalmology. In:Veterinary Ophthalmology, 2nd edn. Gelatt K N pp 529-575. Philadelphia: Lea and Febiger.
  • Petersen-Jones S & Crispin S (2002) BSAVA Manual of Small Animal Ophthalmology. 2nd edn. British Small Animal Veterinary Association. ISBN 0 905214 54 4


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