Felis ISSN 2398-2950

Osteosarcoma

Contributor(s): William Brewer Jr, Jo Morris

Introduction

  • Signs: lameness, bony swelling.
  • Diagnosis: radiography, histopathology.
  • Treatment: surgical excision/amputation.
  • Most common primary bone tumor in the cat (70-80% of primary malignant bone tumors).

Pathogenesis

Pathophysiology

  • Proliferation of neoplastic cells in bone with production of osteoid, bone or cartilage and destruction of normal bone.
  • May cause pathological fracture.
  • Metastasis is less common than in the dog.
  • Proliferation of neoplastic osteoblasts in bone   →   production of osteoid, bone or cartilage matrix around cells and destruction of normal bone. Very painful and therefore weight-bearing reduced.
  • Pathological fracture of long bones may occur as cortex and medulla is destroyed.
  • Mass affecting ribs may impair breathing or   →   pleural effusion.
  • Mass affecting pelvis may   →   constipation.
  • Mass in vertebral column may   →   paraplegia.
  • Dispersal of tumor cells into peripheral blood occurs late in the disease and is much less common than in the dog, hence metastasis is rare.
  • Metastases (when occur) usually seen in lungs (kidney metastases also reported).

Timecourse

  • Weeks to months.
  • Slower for parosteal tumors.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Spugnini E P, Ruslander D & Bartolazzi A (2001) Extraskeletal osteosarcoma in a cat. JAVMA 219 (1), 60-62 PubMed.
  • Heldmann E, Anderson M A & Wagner-Mann C (2000) Feline osteosarcoma 145 cases (1990-1995). JAAHA 36 (6), 518-521 PubMed.
  • Bitetto W V, Patnaik A K, Schrader S C et al (1987) Osteosarcoma in cats - 22 cases (1974-1984). JAVMA 190 (1), 91-93 PubMed.
  • Quigley P J & Leedale A H (1983) Tumours involving bone in the domestic cat - a review of fifty-eight​ cases. Vet Pathol 20 (6), 670-686 PubMed.
  • Liu S K, Dorfam H D & Patnaik A K (1975) Primary and secondary bone tumours in the cat. JSAP 15 (3), 141-156 PubMed.


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