Felis ISSN 2398-2950

Eosinophilic granuloma

Synonym(s): Linear granuloma; Collagenolytic granuloma

Contributor(s): Rosanna Marsella, David Scarff, David Godfrey

Introduction

  • Cause: various hypersensitivity disorders or heritable.
  • Signs: linear or nodular lesions on the skin or oral cavity.
  • Diagnosis: history and clinical signs, and trial treatments for underlying causes.
  • Treatment: identification and correction of underlying cause. Symptomatic.
  • Prognosis: excellent if underlying disorder is identified and treated.

Pathogenesis

Etiology

Hypersensitivity

Ectoparasites

Infection

Other causes

  • Genetic factors.

Pathophysiology

  • Hypersensitivity thought to be causative in most cases.
  • Inflammation (typically hypersensitivity or ectoparasites)   →   cellular infiltration by mast cells and eosinophils.
  • Mast cell degranulation   →   release of eosinophil chemotactic factors.
  • Eosinophilic granules   →   down regulation of inflammation, parasite destruction and collagenolysis.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Leistra W H, van Oost B A & Willemse T (2005) Non-pruritic granuloma in Norwegian Forrest cats. Vet Rec 156 (18), 575-577 PubMed.
  • Bardag√≠ M, Fondati A, Fondevila et al (2003) Ultrastructural study of cutaneous lesions in feline eosinophilic granuloma complex. Vet Dermatol 14 (6), 297-303 PubMed.
  • Fondati A, Fondevila D & Ferrer L (2001) Histopathological study of feline eosinophilic dermatoses. Vet Dermatol 12 (6), 333-338 PubMed.
  • Scarampella F, Abramo F & Noli C (2001) Clinical and histological evaluation of an analogue of palmitoylethanolamide 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque - a pilot study. Vet Dermatol 12 (1), 29-39 PubMed.
  • Power H T & Ihrke P J (1995) Selected feline eosinophilic skin diseases. Vet Clin North Am Small Anim Pract 25 (4), 833-850 PubMed.
  • Mason K V & Evans A G (1991) Mosquito bite-caused eosinophilic dermatitis in cats. JAVMA 198 (12), 2086-2088 PubMed.
  • Pentlarge V (1991) Eosinophilic conjunctivitis in five cats. JAAHA 27 (1), 21-28 VetMedResource.
  • Manning T O, Crane S W, Scheidt V J et al (1987) Three cases of feline eosinophilic granuloma complex (eosinophilic ulcer) and observations on laser therapy. Semin Vet Med Surg (Small Anim) (3), 206-211 PubMed.
  • Gelberg H B, Lewis R M, Felsburg P J et al (1985) Antiepithelial autoantibodies associated with the feline eosinophilic granuloma complex. Am J Vet Res 46 (1), 263-265 PubMed.

Other sources of information

  • Miller W H, Griffin C E & Campbell K L (2013) Feline eosinophilic granuloma complex. In: Muller and Kirk’s Small Animal Dermatology. Eds: Miller W H, Griffin C E & Campbell K L. Elsevier Mosby, St Louis Missouri pp 714.
  • Gross T et al (2005) Ulcerative and crusting dermatoses of the epidermis. In: Skin Diseases of the Dog and Cat, Clinical and Histopathologic Diagnosis. Ames Blackwell Science pp 116
  • Gross T et al (2005) Nodular and diffuse diseases of the dermis with prominent eosinophils, neutrophils or plasma cells. In: Skin Diseases of the Dog and Cat, Clinical and Histopathologic Diagnosis. Ames Blackwell Science pp 342.
  • Rosenkrantz W S (1992) Feline eosinophilic granuloma complex. In: Current Veterinary Dermatology the science and art of therapy. Eds: Griffin C E, Kwochka K W, MacDonald J M. Mosby Year Book, St Louis pp 319.
  • Power H (1990) Eosinophilic granuloma in a family of specific pathogen-free cats. In: Proceedings of the Annual Members Meeting of the American Academy of Veterinary Dermatology and American College of Veterinary Dermatology.


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