ISSN 2398-2950      

Kidney: ischemia

ffelis

Synonym(s): Renal ischemia, ischaemia


Introduction

  • Cause: multiple potential events that can lead to renal ischemia.
  • Signs: same as acute renal failure Kidney: acute renal failure.
  • Diagnosis: histopathology.
  • Treatment: supportive care only to try to prevent renal failure.
  • Prognosis: acute renal failure if renal ischemia not corrected quickly.

Pathogenesis

Etiology

Pathophysiology

  • Sudden impairment of renal blood supply → renal ischemia  →  decreased intracellular ATP (due to mitochondrial dysfunction)  →   decreased function of Na-K and Na-Ca ATP-ase pumps  →  increased intracellular Na and Ca  →  increased intracellular osmotic pressure  →  swelling of tubular cells and sludging and aggregation in renal blood vessels  →  further decrease in renal blood flow.
  • Renal ischemia → increase in oxygen free radical formation → further damage cell membranes (eg through lipid peroxidation).
  • Self-perpetuating secondary injuries during reperfusion injury. 
  • Severe damage to the renal cells  →  acute renal failure and/or chronic changes with fibrosis increasing risk for chronic renal failure Kidney: chronic kidney disease.

Timecourse

  • Acute but can progress to chronic kidney disease.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Prevention

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Brown C A, Rissi D R, Dickerson V M et al (2019) Chronic Renal Changes After a Single Ischemic Event in an Experimental Model of Feline Chronic Kidney Disease. Vet Pathol 56(4), 536-543 PubMed.  
  • Greenbarg E H, Jiménez D A, Nell L A et al (2018) Pilot study: use of contrast-enhanced ultrasonography in feline renal transplant recipients. J Feline Med Surg 20(4), 393-398 PubMed.  
  • Bland S K, Schmiedt C W, Clark M E et al (2017) Expression of Kidney Injury Molecule-1 in Healthy and Diseased Feline Kidney Tissue. Vet Pathol 54(3), 490-510 PubMed.    
  • Rosselli D D, Mumaw J L, Dickerson V et al (2016) Efficacy of allogeneic mesenchymal stem cell administration in a model of acute ischemic kidney injury in cats. Res Vet Sci 108, 18-24 PubMed.    
  • Schmiedt C W, Brainard B M, Hinson W et al (2016) Unilateral Renal Ischemia as a Model of Acute Kidney Injury and Renal Fibrosis in Cats. Vet Pathol 53(1), 87-101 PubMed.  
  • Keir I, Kellum J A (2015) Acute kidney injury in severe sepsis: pathophysiology, diagnosis, and treatment recommendations. J Vet Emerg Crit Care (San Antonio) 25(2), 200-209 PubMed.  
  • Hickey M C, Jandrey K, Farrell K S et al (2014) Concurrent diseases and conditions in cats with renal infarcts. J Vet Intern Med 28(2), 319-23 PubMed
  • Worwag S, Langston C E (2008) Acute intrinsic renal failure in cats: 32 cases (1997-2004). J Am Vet Med Assoc 232(5), 728-32 PubMed.  

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code