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Ibuprofen poisoning

ffelis
Contributor(s):

Rosalind Dalefield

Synonym(s): Ibuprofen toxicity


Introduction

  • Non-steroidal anti-inflammatory agent (NSAID).
  • Ingestion accidental or through treatment by owner.
  • Signs: vomiting, melena.
  • Treatment: symptomatic.
  • Prognosis: variable.
  • No adverse clinical signs or abnormal laboratory parameters if serum ibuprofen concentrations <31 ug/ml.
    Print off the owner factsheetIbuprofen and Naproxen toxicosis  Ibuprofen and Naproxen toxicosis to give to your client.

Pathogenesis

Pathophysiology

  • Cause a prostaglandin deficiency by inhibition of cyclo-oxygenases (COX).
  • Low safety margin as excreted slowly.
  • Low doses cause GI signs.
  • Higher doses also result in organ damage, particularly renal damage.
  • Readily absorbed from gastrointestinal tract, and highly bound by plasma proteins.
  • Interferes with prostaglandin synthesis.
  • Locally irritant to the gastrointestinal tract.
  • Reduces prostaglandin-mediated defense mechanisms in the stomach.
  • Suppresses protective prostaglandin-mediated vasodilation in the kidneys.
  • Toxic dose for dogs, 50 mg/kg with renal failure and death at 300 mg/kg. Corresponding doses for cats approximately half those for dogs.

Timecourse

  • Signs develop within 4-6 hours of acute intoxication.
  • Chronic therapy may also cause signs.
  • Renal failure may develop within 12 hours of massive dose.
  • Can be delayed up to 3-5 days at lower dose.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Spyridakis L K, Bacia J J, Barsanti J A et al (1986) Ibuprofen toxicosis in a dog. JAVMA 189 (8), 918-919.

Other sources of information

  • Mikiciuk M (2001) Nonsteroidal Anti-Inflammatories In: Small Animal Toxicology. Eds: M E Peterson and P A Talcott. Philadelphia: W B Saunders. ISBN: 0 7216 7826 2.
  • Osweiler G D (1995) Toxicology. Philadelphia: Williams and Wilkins. ISBN: 0 6830 6664 1.

Organisation(s)

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