Felis ISSN 2398-2950

Hair follicle: neoplasia

Synonym(s): Pilomatrixoma, trichoepithelioma, dilated pore - Winer, trichoblastoma, tricholemmoma.

Contributor(s): Irene Rochlitz, David Scarff

Introduction

  • Cause: tumors derived from the structures of the hair follicle.
  • Uncommon (approximately 1% of skin tumors).
  • Signs: well-circumscribed, firm and usually solitary in middle-aged to older cats.
  • Diagnosis: skin biopsy, fine needle aspiration.
  • Treatment: surgical excision, cryotherapy.
  • Prognosis: slow growing, usually non-invasive and rarely metastasize.

Pathogenesis

Etiology

Trichoepithelioma

  • Benign neoplasm arising from keratinocytes that differentiate towards all three segments of the hair follicle; hair follicle sheath, follicle sheath, hair matrix.

Tricholemmoma

  • Benign neoplasm arising from keratinocytes of the outer root sheath of hair follicles.

Dilated pore of Winer

  • Benign follicular neoplasm.
  • Cause of this lesion unknown. Most evidence favors a developmental origin leading to hair follicle hyperplasia.

Pilomatrixoma

  • Neoplasm arising from the hair matrix.
  • Rarely invasive or metastatic.

Trichoblastoma

  • Neoplasms presumably derived from the primitive hair germ epithelium.
  • Rarely metastatic.
  • Three basic subtypes of which the trabecular type is most common in cats.

Pathophysiology

  • Tumors derived from the structures of the hair follicle.

Timecourse

  • Months.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Abramo F, Pratesi F, Cantile C et al (1999) Survey of canine and feline follicular tumors and tumor-like lesions in central Italy. JSAP 40 (10), 479-481 PubMed.

Other sources of information

  • Scott D W, Miller W H and Griffin C E (1995) Small Animal Dermatology. 5th Edn. Philidelphia: WB Saunders.


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