ISSN 2398-2950      

Feline progressive histiocytosis (FPH)

ffelis

Introduction

  • Cause: proliferation of dendritic cells/macrophages commonly progressing on to malignant histiocytic sarcoma.
  • Signs: slow growing, non-painful, solitary or multiple, firm, intradermal, papules or nodules.
  • Diagnosis: fine needle aspirate → histopathology → immunohistochemistry ± internal imaging.
  • Treatment: prompt wide excision of solitary lesions otherwise no known effective treatment.
  • Prognosis: very poor but progression slow.
Consulting a specialist dermatologist or oncologist is recommended to check for novel therapies.

Pathogenesis

Etiology

  • Exact etiology unknown: likely a primary low-grade neoplasia of cutaneous dendritic cells with initial indolent behavior.
  • Proliferation of cutaneous dendritic cells (DCs)/macrophages (dermal DCs and/or epidermal Langerhans cells) → accumulated mutations lead to evolution of malignant histiocytic neoplasia.

Predisposing factors

General

  • Unknown.

Specific

  • Unknown.

Pathophysiology

  • Proliferation of cutaneous dendritic cells/macrophages → evolution into malignant histiocytic cells → peripheral lymph nodes → neoplastic invasion of multiple internal organs.

Timecourse

  • Long/chronic - commonly limited to the skin for long time period.

Epidemiology

  • Very low incidence.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Coste M, Prata D, Castiglioni V, Minoli L, Etienne-Raffestin C-L, Boulouha L, Moreau S, Lagadic M (2019) Feline progressive histiocytosis: a retrospective investigation of 26 cases and preliminary study of Ki67 as a prognostic marker. J Vet Diag Invest 31(6), 801-808 PubMed.
  • Affolter V K, Moore P F (2006) Feline Progressive Histiocytosis. Vet Path 43(5), 646-655 PubMed.

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