Felis ISSN 2398-2950

Eosinophilic plaque

Contributor(s): Rosanna Marsella, David Scarff, David Godfrey

Introduction

  • Cause: various hypersensitivity disorders or heritable.
  • Signs: erythematous, raised, exudative lesions anywhere on the body including oral cavity.
  • Diagnosis: history and clinical signs, and trial treatments for underlying causes.
  • Treatment: identification and correction of underlying cause. Symptomatic.
  • Prognosis: excellent if underlying disorder is identified and treated.

Pathogenesis

Etiology

Hypersensitivity

Ectoparasites

Infection

Other causes

  • Genetic factors.

Pathophysiology

  • Hypersensitivity thought to be causative in most cases.
  • Inflammation (typically hypersensitivity or ectoparasites)   →   cellular infiltration by mast cells and eosinophils.
  • Mast cell degranulation   →   release of eosinophil chemotactic factors.
  • Eosinophilic granules   →   down regulation of inflammation, parasite destruction and collagenolysis.
  • Self trauma   →   ulceration   →   2° bacterial infection.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Wildermuth B E, Griffin C E & Rosenkrantz (2011) Response of feline eosinophilic plaques and lip ulcers to amoxicillin trihydrate-clavulanate potassium therapy: a randomized, double-blind placebo-controlled prospective study. Vet Dermatol 23 (2), 110-8 PubMed.
  • Lee M, Bosward K L, Norris J M (2010) Immunohistochemical evaluation of feline herpes-1 infection in feline eosinophilic dermatoses or stomatitis. J Feline Med Surg 12 (2), 72-79 PubMed.
  • Bardag√≠ M, Fondati A, Fondevila D et al (2003) Ultrastructural study of cutaneous lesions in feline eosinoophilic granuloma complex. Vet Dermatol 14 (6), 297-303 PubMed.
  • Kimura T, Kano R, Maeda S et al (2003) Expression of RANTES mRNA in skin lesions of feline eosinophilic plaque. Vet Dermatol 14 (5), 269-273 PubMed.
  • Fondati A, Fondevila D & Ferrer L (2001) Histopathological study of feline eosinophilic dermatoses. Vet Dermatol 12 (6), 333-338 PubMed.
  • Scarampella F, Abramo F & Noli C (2001) Clinical and histological evaluation of an analogue of palmitoylethanolamide 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque - a pilot study. Vet Dermatol 12 (1), 29-39 PubMed.
  • Power H T, Ihrke P J (1995) Selected feline eosinophilic skin diseases. Vet Clin North Am Small Anim Pract 25 (4), 833-850 PubMed.
  • Moriello K A, Kunkle G, Miller L M et al (1990) Lack of autologous tissue transmission of eosinophilic plaques in cats. Am J Vet Res 51 (7), 995-998 PubMed.

Other sources of information

  • Miller W H, Griffin C E & Campbell K L (2013) Feline eosinophilic granuloma complex. In: Muller and Kirk's Small Animal Dermatology. Miller  WH, Griffin C E & Campbell K L (eds). Elsevier Mosby, St Louis, Missouri, pp 714.
  • Gross T et al (2005) Ulcerative and crusting dermatoses of the epidermis. In: Skin Diseases of the Dog and Cat, Clinical and Histopathologic Diagnosis. Ames Blackwell Science, pp 116.
  • Gross T et al (2005) Nodular and diffuse diseases of the dermis with prominent eosinophils, neutrophils or plasma cells. In: Skin Diseases of the Dog and Cat, Clinical and HIstopathologic Diagnosis. Ames Blackwell Science, pp 342.
  • Rosenkrantz W S (1992) Feline eosinophilic granuloma complex. In: Griffin C E, Kwochka K W, MacDonald J M (eds) Current Veterinary Dermatology: the Science and Art of Therapy. Mosby Year Book, St Louis, pp 319.


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