Felis ISSN 2398-2950

Degenerative myelopathy

Synonym(s): CDRM Chronic degenerative radiculomyelopathy

Contributor(s): Agnes Delauche, Agnes Delauche, Robin Franklin

Introduction

  • Very rare in the cat, few documented cases.
  • Cause: primary cases may be immune-mediated; secondary to storage diseases Storage disease.
  • Signs: progressive ataxia, paresis, loss of hindlimb proprioception; visceral function and pain sensation remain intact.
  • Diagnosis: signs and negative myelographic findings.
  • Treatment: none.
  • Prognosis: poor; expect deterioration.

Pathogenesis

Predisposing factors

General

Pathophysiology

  • Primary degenerative myelopathy is a white matter condition with axonal degeneration and then Wallerian degeneration.
  • Immune-mediated degeneration of dorsolateral funiculi of white matter of spinal cord and dorsal spinal roots   →   loss of nerve function. This has been shown to be the case in the German Shepherd Dog but insufficient work in the cat.

Timecourse

  • Very variable but inevitably progressive.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Mesfin G M, Kusewitt D and Parker A (1980) Degenerative myelopathy in a cat. JAVMA 176 (1), 62-4 PubMed.


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