ISSN 2398-2950      

Congenital hypotrichosis

ffelis

Synonym(s): Hereditary hypotrichosis


Introduction

  • Cause: rare congenital disorder of hair follicles.
  • Signs: decreased or absent hair coat from birth.
  • Diagnosis: clinical signs +/- skin biopsy Biopsy: skin.
  • Treatment: none.
  • Prognosis: cosmetic only.
  • Pili tortiis a separate, rare, congenital disorder with rotation of the secondary hairs.
  • Diffuse thinning of hair coat by 10 days  →  generated alopecia, pedal dermatitis and paronychia.

Pathogenesis

Etiology

  • Autosomal recessive in Birman and Siamese cats.
  • Mode of inheritance not elucidated in other breeds.

Pathophysiology

  • Congenital non-color-linked hair loss +/- additional ectodermal defects.
  • Genetic coding for hypotrichosis (Birman and Siamese)   →   hair follicles and adnexa (sebaceous glands, sweat glands and arrector pili muscles) absent or hypoplastic and decreased in number   →   hairless or thin coat from birth.
  • May be associated with thymic aplasia in Burmese Hypotrichosis with thymic aplasia.
  • Failure of ectodermal (hypotrichosis) and entodermal (thymic aplasia) development.

Timecourse

  • Lifelong.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Casal M L, Straumann U, Sigg C et al (1994) Congenital hypotrichosis with thymic aplasia in nine Birman kittens. JAAHA 30 (6), 600-602 VetMedResource.
  • Geary M R & Baker K P (1986) The occurrence of pili torti in a litter of kittens in England. JSAP 27 (2), 85-88 VetMedResource.

Other sources of information

  • Foil C S (1995) The skin. In:Veterinary Pediatrics. 2nd edn. Ed:J D Hoskins. Philadelphia: W B Saunders.

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