Felis ISSN 2398-2950

Brush border membrane disease

Contributor(s): Ed Hall, Philip K Nicholls, Kenneth Simpson

Introduction

  • Cause: primary deficiencies of brush border enzymes, eg lactase, sucrase (absolute deficiency has not been documented in cats); deficiencies of disaccharidase, brush border peptidase due to small intestinal diseases, eg eosinophilic enteritis, lymphocytic enteritis Lymphocytic / plasmacytic enteritis.
  • Signs: chronic diarrhea.
  • Treatment: treat primary disease, diet.
  • Prognosis: good, with treatment.

Pathogenesis

Etiology

  • Small intestinal diseases.
  • Deficiency of specific brush border enzymes.

Predisposing factors

General

  • Small intestinal bacterial overgrowth (not documented in cats).
  • Eosinophilic enteritis Gastroenteritis.
  • Lymphocytic/plasmacytic enteritis.
  • Gluten-sensitive enteropathy (not documented in cats).
  • Lymphosarcoma Lymphoma.

Pathophysiology

  • Small intestinal mucosal damage  →   reduction in activity of disaccharidase/brush border peptidase   →   malabsorption of disaccharides/oligopeptides.
  • Specific deficiency of brush border enzyme, ie lactase, sucrase, enterokinase   →   malabsorption of lactose/sucrose and protein.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers


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