ISSN 2398-2950      

Birman neutrophil granulation anomaly

ffelis
Contributor(s):

Introduction

  • Cause: rare hereditary trait in Birman cats resulting in altered neutrophil cytoplasm granularity.
  • Signs: increased granularity of the cytoplasm of abnormal neutrophils that resemble immature cells. Neutrophil function is unaffected.
  • Diagnosis: cytology.
  • Treatment: none required.
  • Prognosis: good.

Pathogenesis

Etiology

  • An autosomal recessive hereditary abnormality resulting in increased granularity of the cytoplasm of abnormal neutrophils that resemble the cytoplasm of immature cells. Granules may appear red/azurophilic (eosinophilic) on Wright-Giemsa staining. Neutrophil function (eg phagocytosis, oxidative metabolism, bacteriocidal activity) is unaffected.

Pathophysiology

  • Affected cats have fine eosinophilic granules (Romanowsky or Wright-Giemsa stains) in the cytoplasm of their neutrophils due to an alteration in the content of lysosomal granules with increased affinity for acidic dyes.

Timecourse

  • Unknown but likely present from birth.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Thompson J C (2009) Unusual granulation of neutrophils from Siamese cats and possible link with granulation in Birman cats. NZ Vet J 57 (1), 70 ResearchGate
  • Segev G, Klement E, Aroch I (2006) Toxic Neutrophils in Cats: Clinical and Clinopathologic Features, and Disease Prevalence and Outcome - A Retrospective Case Control Study. J Vet Intern Med (20) (1), 20-31 PubMed.
  • Hirsch V M, Cunningham T A (1984) Hereditary anomaly of neutrophil granulation in Birman cats. Am J Vet Res 45 (10), 2170-2174 PubMed.

Other sources of information

  • Hostetter S J (2012) Neutrophil Function in Small Animals. Vet Clin Small Animal 42 (1), 151-171 PubMed.
  • Little S (2012) The Cat Clinical Medicine and Management. Chapter 25, pp 678.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code