Felis ISSN 2398-2950

Feline sarcoma virus

Synonym(s): Feline sarcoma virus, FeSV

Contributor(s): Susan Dawson, Margaret J Hosie, Brian J Willett

Introduction

Classification

Taxonomy

  • Family: Retrovirus.
  • Type: Gammaretrovirus.

Etymology

  • Retro because the viral RNA is reverse transcribed into DNA (proviral DNA).

Active Forms

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Clinical Effects

Epidemiology

Transmission

  • The resulting tumors contain both FeLV and FeSV which may be transmitted experimentally.
  • FeSV is not transmitted between cats in nature; the virus arises de novo in cats persistently infected with FeLV.
  • FeLV is transmissable between cats by direct contact.

Pathological effects

  • FeSV will not arise in cats immune to FeLV, thus protection against FeLV protects against FeSV.
  • FeSVs induce multiple, usually subcutaneous, fibrosarcomas of young cats <5 years of age (the more common solitary fibrosarcoma of the older cat (mean age 10 years) is not caused by FeSV).

Control

Control via chemotherapies

  • Unlikely to work, however, a protocol is given by Keller and Helfand (1994) for those desperate to try.

Control via environment

  • As for FeLV.

Vaccination

  • Since FeSV cannot occur without FeLV, FeLV vaccination will also protect cats from FeSV.

Other countermeasures

  • Tumors usually recur after surgery.
  • Since the prognosis for FeSV fibrosarcomas is grave, euthanasia may well be the best option.

Diagnosis

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Keller E T, Helfand S C (1994) Clinical management of soft-tissue sarcomas. In: Consultations in feline internal medicine 2.  Ed John R. August. W B Saunders Co., Harcourt Brace Jovanovich, Inc. The Curtis Center, Independence Square West, Philadelphia, PA 19106. pp 3-12.
  • Hardy W D Jr (1987) Oncogenic viruses of cats: the feline leukemia and sarcoma viruses.In: Diseases of the Cat: Medicine and Surgery Ed Holzworth, J. W B Saunders Co., Harcourt Brace Jovanovich, Inc. The Curtis Center, Independence Square West, Philadelphia, PA 19106. pp 256-258.

Organization(s)

  • Companion Animal Diagnostics, Veterinary Diagnostic Services.Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, Scotland. Tel: + 44 141 330 5777; Fax: + 44 141 330 5748; E-mail:  companion@vet.gla.ac.uk .

ADDED