ISSN 2398-2985      

Sulfadiazine

Jreptile

Introduction

Name

  • Sulfadiazine.

Class of drug

  • Sulfonamide antibiotic.
  • Generally potentiated with trimethoprim.

Description

Chemical name

  • 4-amino-N-pyrimidin-2-ylbenzenesulfonamide.

Molecular formula

  • C10H10N4O2S.

Molecular weight

  • 250.27.

Physical properties

  • Trimethoprim: odorless, bitter-tasting, white to cream-colored crystals or crystalline powder. Very slightly soluble in water and slightly soluble in alcohol.
  • Sulfadiazine: odorless or nearly odorless, white to slightly yellow powder. Practically insoluble in water and sparingly soluble in alcohol.

Storage requirements

  • Store at room temperature in tight containers.

Uses

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Indications

  • Fairly broad spectrum of activity for potentiated sulfas.
  • Gram-positive bacteria that are generally susceptible include most streptococci, many strains of Staphylococcus and Nocardia.
  • Many gram-negative organisms of the family Enterobacteriaceae are susceptible, but not Pseudomonas aeruginosa.
  • Some protozoa (Toxoplasma, coccidia, Pneumocystis) are also inhibited by the combination.
  • Little activity against most anaerobes.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Antacids
  • May decrease bioavailability of sulfonamides if administered concurrently.
Cyclosporine
  • Trimethoprim/sulfa may increase the risk of nephrotoxicity.
Digoxin
  • Trimethoprim/sulfa may increase digoxin levels.
Diuretics
  • May increase the risk for thrombocytopenia.

With diagnostic tests

  • Text here

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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