ISSN 2398-2985      

Neostigmine

Jreptile

Introduction

Name

  • Neostigmine bromide.

Class of drug

  • Anticholinesterase.

Description

Chemical name

  • 3-(dimethylamino)carbonyloxy-N,N,N-trimethylbenzenaminium.

Molecular formula

  • C12H19N2O2.

Molecular weight

  • 223.3.

Physical properties

  • Odorless, bitter-tasting, white crystalline powder.
  • Very soluble in water and soluble in alcohol.

Storage requirements

  • Tablets should be stored at room temperature in tight containers.
  • Neostigmine methylsulfate injection should be stored at room temperature and protected from light; avoid freezing.

Uses

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Indications

  • It is used in reptiles to reverse the action of non-depolarizing neuromuscular blocking agents:
    • Rocuronium is uncommonly used to intubate chelonians.
    • Gallamine is occasionally used to immobilize crocodilians.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Aminoglycosides, clindamycin, lincomycin, polymyxins and propranolol may antagonize the effect of neostigmine.
  • Neostigmine enhances the effect of suxamethonium, but antagonizes the effect of non-depolarizing muscle relaxants.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Scarpa Bosso A C, Quagliatto Santos A L, Machado Brito F M et al (2009) The use of rocuronium in giant Amazon turtle Podocnemis expansa (Schweigger, 1812) (Testudines, Podocnemididae). Acta Cirurgica Brasileira 24 (4), 3411-315.
  • Kaufman G E, Seymour R E, Bonner B B et al (2003) Use of rocuronium for endotracheal intubation of North American Gulf Coast box turtles. J Am Vet Med Assoc 222 (8), 1111-1115.

Other sources of information

  • Fleming G J (2014) Crocodiles (Crocodiles, Alligators, Caima, Gharial). In: Zoo Animal and Wildlife Immobilization and Anesthesia. 2nd edn. Eds: West G, Heard D & Caulkett N. Wiley-Blackwell, USA. pp 325-336.
  • Mader D R (2006) Ed. Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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