ISSN 2398-2985      

Methadone

Jreptile

Introduction

Name

  • Methadone.

Class of drug

  • Scheduled Class II opioid (narcotic).
  • Controlled substance, schedule 2/CLASS A controlled drug.

Description

 

Molecular formula

  • C21H27NO.

Molecular weight

  • 309.4

Physical properties

  • A clear colorless to pale yellow solution.
  • Tablets.

Storage requirements

  • Store at room temperature (15-30°C/59-86°F).
  • Protect from light.
  • The medication needs to be stored under lock.

Uses

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Indications

  • A synthetic opioid agonist used as a pre-anesthetic agent and for short-term pain control.
  • Often combined with other anesthetics.
  • It is often used with a tranquilizer, eg diazepam Diazepam to produce deep sedation.
  • At equivalent doses to morphine Morphine the incidence of vomiting in dogs seems to be lower.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Central nervous system (CNS) depressants (anesthetics, antihistamines, barbiturates, phenothiazines, tranquilizers, etc).
  • May cause increased CNS or respiratory depression if used with narcotic analgesics.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Perpinan D (2018) Reptile anaesthesia and analgesia. Comp Anim 23 (4), 2-9.

Other sources of information

  • BSAVA (2015) Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
  • US Food & Drug Administration (FDA). Website: www.fda.gov.
  • Veterinary Medicines Directorate (VMD) Adverse Reaction Reporting. Website: www.vmd.defra.gov.uk.
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