ISSN 2398-2985      

Meloxicam

Jreptile

Synonym(s): Metacam, Mobi, Mobicox


Introduction

Name

  • Meloxicam.

Class of drug

  • Non-steroidal anti-inflammatory drug (NSAID).

Description

Chemical name

  • 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1$l^{6},2-benzothiazine-3-carboxamide.

Molecular formula

  • C14H13N3O4S2.

Molecular weight

  • 351.39.

Physical properties

  • Pale yellow powder.
  • Practically insoluble in water, with higher solubility observed in strong acids and bases.

Storage requirements

  • Store at room temperature.

Uses

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Indications

  • Possibly to alleviate mild to moderate musculoskeletal pain and inflammation. No study has confirmed its efficacy at producing analgesia in reptiles.
  • The use of other analgesics, eg tramadol, morphine, may be more adequate in reptiles.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Fluoroquinolones
  • Increase risk of convulsions (in man).
Anti-hypertensives, eg beta-blockers
  • Hypotensive effects may be antagonized.
Diuretics, aminoglycosides
  • May increase risk of nephrotoxicity.
Aspirin, corticosteroids, warfarin, other NSAIDs
  • Increased risk of bleeding.
Digoxin
  • NSAIDs may increase serum levels.

with diagnostic tests

  • May cause false low values for T3 and T4.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Uney K, Altan F, Aboubakr M et al (2016) Pharmacokinetics of meloxicam in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections. Am J Vet Res 77 (5), 439-444 PubMed.
  • di Salvo A, Giorgi M, Catanzaro A et al (2016) Pharmacokinetic profiles of meloxicam in turtles (Trachemys scripta elegans) after single oral, intracoelomic and intramuscular administrations. J Vet Pharmacol Therap 39 (1), 102-105 PubMed.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 195.
  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Tennant Bryn (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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