ISSN 2398-2985      

Ketoprofen

Jreptile

Synonym(s): Ketofen, Orudis, Oruvail


Introduction

Name

  • Ketoprofen.

Class of drug

  • Propionic acid, non-steroidal anti-inflammatory drug (NSAID).

Description

Chemical name

  • (RS)-2-(3-benzoylphenyl)propanoic acid.

Molecular formula

  • C16H14O3.

Molecular weight

  • 254.28.

Physical properties

  • Off white to white, fine to granular powder.
  • Practically insoluble in water, but freely soluble in alcohol.

Storage requirements

  • Oral form: room temperature in tight, light resistant containers.
  • Injectable form: room temperature.

Uses

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Indications

  • To control mild to moderate pain.
  • Not recommended for pre-operative administration.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • NSAIDs
  • Do not administer concurrently.
  • Increased risk of GI ulceration.
  • Increased risk of convulsions (man).
Diuretics
  • Increased risk of nephrotoxicity.
Anti-hypertensive agents
  • NSAIDs may antagonize the hypotensive effects of anti-hypertensives, eg beta-blockers.
Anti-coagulants
  • Do not administer concurrently.
Other substances
  • Do not mix with other substances in the same syringe.

with diagnostic tests

  • May falsely elevate glucose and bilirubin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Thompson K A, Papich M G, Higgins B et al (2018) Ketoprofen pharmacokinetics of R- and S-isomers in juvenile loggerhead sea turtles (Caretta caretta) after single intravenous and single-and multidose intramuscular administration. J Vet Pharmacol Therapeutics 41(2), 340-348 PubMed.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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