ISSN 2398-2985      

Clarithromycin

Jreptile

Synonym(s): Kalricid


Introduction

Name

  • Clarithromycin.

Class of drug

  • Macrolide antibiotic.

Description

Chemical name

  • 6-O-Methylerythromycin.

Molecular formula

  • C38H69NO13.

Molecular weight

  • 747.96.

Physical properties

  • White to off-white crystalline powder.
  • Practically insoluble in water, slightly soluble in ethanol, and soluble in acetone

Storage requirements

  • Store at room temperature, in well-closed containers and protected from light.
  • After reconstiting the oral solution, it should be stored at room temperature and discarded after 14 days.
  • Do not refrigerate.

Uses

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Indications

  • It can be used to treat upper respiratory tract disease caused by Mycoplasma spp in tortoises.
  • Most bacterial infections in reptiles are caused by gram-negative bacteria, so its use is limited to those microorganisms reportedly sensitive to clarithromycin or when sensitivity tests demonstrate that clarithromycin can be useful.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Methylprednisolone, theophylline.
  • Increased serum levels of these drugs.
  • Enhanced absorption of digoxin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Wimsatt J, Tothill A, Offermann C F et al (2008) Long-term and per rectum disposition of clarithromycin in the desert tortoise (Gopherus agassizii). J Am Assoc Lab Anim Sci 47 (4), 41-45 PubMed.
  • Wimsatt J, Johnson J, Mangone B A et al (1999) Clarithromycin pharmacokinetics in the desert tortoise (Gopherus agassizii). J Zoo Wildl Med 30 (1), 36-43 PubMed.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.
  • McArthur S, Wilkinson R & Meyer J (2004) Medicine and Surgery of Tortoises and Turtles. Blackwell Publishing, UK. pp 579.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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