ISSN 2398-2985      

Cisapride

Jreptile

Synonym(s): Prepulsid


Introduction

Name

  • Cisapride.

Class of drug

  • Prokinetic agent (promotes gastric emptying).

Description

Chemical name

  • (±)-cis-4-amino-5-chloro-N-(1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl)-2-methoxybenzamide.

Molecular formula

  • C23H29ClFN3O4.

Molecular weight

  • 466.

Storage requirements

  • Store at room temperature.
  • Keep out of light and keep dry.

Uses

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Indications

  • Management of:
    • Gastrointestinal stasis/constipation Constipation .
    • Reduced gastrointestinal motility (constipation is a common problem in reptiles). 

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Opioid analgesics and antimuscarinics, eg atropine Atropine may antagonize cisapride's effects.
  • Fatal arrhythmia may be seen in conjunction with:
    • Erythromycin, clarythromycin Clarithromycin, troleandomycin.
    • Itraconazole [Itraconazole], ketoconazole [Ketoconazole], fluconazole [Fluconazole] and miconazole.
  • Increases bioavailability of cyclosporine.
  • Increases absorption of aspirin, acetaminophen, diazepam [Diazepam], ethanol.
  • May have synergistic effects when used with H2 receptor antagonists.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK.
  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Elsevier Saunders, USA. pp 564.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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