ISSN 2398-2985      

Benzylpenicillin

Jreptile
Contributor(s):

Vetstream Ltd

Anna Meredith

Synonym(s): Penicillin G, Penicillin G potassium, Benzylpenicillin potassium salt, Penicillin G sodium, Benzylpenicillin sodium salt


Introduction

Name

  • Benzylpenicillin sodium salt.
  • Benzylpenicillin potassium salt.

Class of drug

  • Penicillin antibiotic.

Description

Chemical name

  • Sodium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • Potassium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate.

Molecular formula

  • Benzylpenicillin sodium: C16H17N2NaO4S.
  • Benzylpenicillin potassium: C16H17KN2O4S.

Molecular weight

  • Benzylpenicillin sodium: 356.37.
  • Benzylpenicillin potassium: 372.48.

Physical properties

  • Benzylpenicillin sodium: white/yellow crystalline powder with a slight odor.
  • Benzylpenicillin potassium: liquid.

Uses

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Indications

  • Used parenterally to treat serious infections caused by sensitive organisms, eg Streptococcus spp, Clostridium spp, Borrelia borgderferi, some Staphylococcus spp and fusospirochetes.
  • Useful to treat Group A beta-hemolytic streptococci, many gram-positive anaerobes, spirochetes, gram-negative aerobic cocci, and some gram-negative aerobic bacilli.
  • Little efficacy to treat most gram-negative aerobic and anaerobic bacteria. 
  • When used for 'blind' therapy of undiagnosed serious infections penicillins may be given in conjunction with gentamicin Gentamicin and/or metronidazole Metronidazole.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

Probenecid
  • Blocks the renal tubular excretion of penicillins, producing higher and more prolonged plasma concentrations.
Aminoglycosides, eg gentamicin
  • May inactivate penicillins when mixed together in parenteral solutions. However, there is a synergistic effect between penicillins and aminoglycosides against certain bacteria. 
Streptomycin
  • Synergistic action, however, as their pharmacokinetics differ, the use of such compound preparations is generally thought to be unjustified.
Bacteriostatic antibiotics (tetracyclines, chloramphenicol, erythromycin)
  • ​Use of bacteriostatic antibiotics together with penicillins is not recommended.

With diagnostic tests

  • Serum sodium or potassium may be altered when given sodium or potassium salts. 

Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Hedley J (2020) Ed Small Animal Formulary. Part B: Exotic Pets. 10th edn. BSAVA, UK. pp 228.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA, UK. ISBN: 9781905319657.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.

Organisation(s)

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