ISSN 2398-2985      

Aminophylline

Jreptile

Synonym(s): Theophylline-ethylenediamine, Theophyllamine


Introduction

Name

  • Aminophylline.

Class of drug

  • Methylxanthine

Description

Chemical name

  • 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compound + 1,2-ethanediamine (2:1).
  • Theophylline compound + ethylenediamine.

Molecular formula

  • C16H24N10O4.

Physical properties

  • Aminophylline is a mixture of theophylline and ethylenediamine, the latter increases the water solubility of theophylline.
  • 100 mg of aminophylline is equivalent to 79 mg of theophylline.
  • Aminophylline occurs as bitter-tasting, white or slightly yellow granules or powder with a slight ammoniacal odor. Aminophylline is soluble in water and insoluble in alcohol.

Storage requirements

  • Store in tight, light-resistant containers at room temperature.

Uses

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Indications

  • To dilate bronchi.
  • Pulmonary edema.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Do not mix aminophylline in a syringe with other drugs.
Beta-adrenergic blockers, eg propranolol
  • May antagonize each others effect.
Halothane
  • May increase incidence of cardiac dysrhythmias [Halothane].
Ketamine
  • May increase incidence of seizures [Ketamine].
Phenytoin
  • Theophylline may decrease effect of phenytoin.
Pancuronium
  • Theophylline may decrease the effects of pancuronium.
Agents which may increase theophylline effect
  • Cimetidine [Cimetidine].
  • Erythromycin.
  • Allopurinol Allopurinol.
  • Thiabendazole.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Mader D R (2006) Ed. Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.
  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Blackwell Publishing, USA. pp 1296.
    • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.
     

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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