ISSN 2398-2985      

Vitamin E

6guinea pig

Synonym(s): Alpha-tocopherol


Introduction

Name

  • Alpha-tocopherol.

Class of drug

  • Vitamin.

Description

Chemical name

  • (+)-2,5,7,8-tetramethyl-2-(4812-trimethyltridecyl)-6-chromanol.

Molecular formula

  • C29H50O2.

Molecular weight

  • 430.69.

Physical properties

  • Water insoluble pale viscous oil.
  • Boiling point 210°C/410°F.
  • Melting point 2-3°C/35.6-37.4°F.

Storage requirements

  • Alpha-tocopherol is destroyed by light and oxygen, but is relatively heat stable.
  • Viability is lost during significant heating and freezing.
  • Encapsulation protects against vitamin E destruction.
  • Store at temperatures less than 25°C/77°F.

Uses

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Indications

  • Vitamin E deficiency is rare in guinea pigs but can be seen if the diet is not correct. It will cause muscular distrophy, stiffness and reluctance to move, spontaneous hind limb weakness, paralysis and even death. It can also cause infertility.
  • Also used as a topical anti-inflammatory agent.
  • May improve reproductive efficiency by reducing germ cell oxidative damage.
  • Its use has been proposed in demodicosis and hepatic fibrosis.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • May enhace vitamin A absorption, utilization and storage.
  • May alter cyclosporin pharmacokinetics.

with diagnostic tests

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Schneider C (2005) Review: chemistry and biology of vitamin E. Mol Nutr Food Res 49, 7-30.

Other sources of information

  • BNF Publications (2017) BNF Online - The British National Formulary. Website: www.BNF.org. Last accessed 6th April 2017.
  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Higdon J, Drake V J & Traber M G (2008) Vitamin E. Oregon State University, Linus Pauling Institute, Micronutrient Information Center. Website: http://lpi.oregonstate.edu.
  • Richardson V C G (2000) Diseases of Domestic Guinea Pigs. 2nd edn. Blackwell Science, UK. pp 144.
  • McDonald P, Edwards R A, Greenhalgh J F D & Morgan C A (1996) Animal Nutrition. 5th edn. Longman.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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