ISSN 2398-2985      

Vitamin C

6guinea pig

Synonym(s): Ascorbic acid, L-ascorbic acid, Vita-C, Dull-C, Redoxon


Introduction

Name

  • Vitamin C.

Class of drug

  • Vitamin.

Description

Chemical name

  • (5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxy-2(5H)-furanon.

Molecular formula

  • C6H8O6.

Molecular weight

  • 176.12.

Physical properties

  • White to slightly yellow crystal or powder.
  • Freely soluble in water and sparingly soluble in alcohol.

Storage requirements

  • Protect from air and light.
  • Store vials and multi-dose vials in the refrigerator and open while still cold.
  • Vitamin C slowly darkens upon light exposure. Slight discoloration does not affect potency.

Uses

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Indications

  • It needs to be exogenously supplied in guinea pigs as they are not able to synthetize in vivo enough vitamin C to meet their nutritional needs Nutrition: overview.
  • Its use to acidify urine is questionable and probably ineffective in guinea pigs.
  • Used to reduce methemoglobinemia associated with paracetamol (acetaminophen) toxicity.
  • Supplemental vitamin C may be required in caquexic patients of those requiring nutritional support.
  • Supplemental vitamin C in guinea pigs speeds healing of wounds and may be beneficial in the coadjuvant treatment of many other conditions.
  • The consequences of vitamin C deficiencies are numerous and important in guinea pigs. Hypovitaminosis C (vitamin C deficiency) is commonly referred as scurvy Vitamin C deficiency.

Administration

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Pharmacokinetics

Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Schencke C, Vasconcellos A, Sandoval C et al (2016) Morphometric evaluation of wound healing in burns treated with Ulmo (Eucryphia cordifolia) honey alone and supplemented with ascorbic acid in guinea pig (Cavia porcellus). Burns & Trauma 4, 25 PubMed.

Other sources of information

  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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