ISSN 2398-2985      

Vitamin A

6guinea pig

Synonym(s): Retinal, Retinol, Retinoic acid


Introduction

Name

  • Retinol.

Class of drug

  • Vitamin.

Description

Chemical name

  • 3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-l-yl)nona-2,4,6,8-tetraen-l-ol.

Molecular formula

  • C20H30O.

Molecular weight

  • 286.

Physical properties

  • Yellow crystals or an orange solid.
  • Practically water insoluble.
  • Light sensitive.
  • Non-flammable.

Storage requirements

  • Protect from exposure to light.
  • Keep containers tightly closed to prevent oxidation.

Uses

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Indications

  • Hypovitaminosis A: extremely rare in guinea pigs.
  • Some chemotherapeutic protocols for certain neoplasias (specific leukemias, mammary tumors).
  • Certain skin diseases, such as seborrheic dermatitis (retinoids: isotretinoin, tretinoin).

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Cholestyramine and neomycin may affect oral uptake and absorption as does mineral oil.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Blumhoff R & Blumhoff H K (2006) Overview of retinoid metabolism and function. J Neurobiol 66 (7), 606-630 PubMed.
  • Collins M D & Mao G E (1999) Teratology of retinoids. Ann Rev Pharmacol & Toxicol 39 (1), 399-430.

Other sources of information

  • BNF Publications (2017) BNF Online - The British National Formulary. Website: www.BNF.org. Last accessed 6th April 2017.
  • Higdon J, Drake V J & Russell R M (2007) Vitamin A. Oregon State University, Linus Pauling Institute, Micronutrient Information Center. Website: http://lpi.oregonstate.edu.
  • McDonald P, Edwards R A, Greenhalgh J F D & Morgan C A (1996) Animal Nutrition. 5th edn. Longman.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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