ISSN 2398-2985      

Ranitidine

6guinea pig

Synonym(s): Ranitidine HCl, Zantac


Introduction

Name

  • Ranitidine.
  • Usually available and used as the hydrochloride salt, ranitidine hydrochloride.
  • Ranitidine bismuth citrate also used in human medicine.

Class of drug

  • Histamine (H2) receptor antagonist.

Description

Chemical name

  • N[2-[[[5-[(dimethylamino)methyl]-2furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine.

Molecular formula

  • C13H22N4O3S.

Molecular weight

  • 350.87 g.

Physical properties

  • White to pale yellow granular substance.
  • Water soluble.
  • Slightly bitter taste.
  • Sulfur-like odor.

Storage requirements

  • Tablets: store in tight, light-resistant containers at room temperature.
  • Injectable: store at room temperature and protected from light.
  • A slight darkening of the injectable solution does not affect the potency of the drug.

Uses

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Indications

  • Indicated as a useful prokinetic drug for the treatment of gut stasis Gastrointestinal stasis.
  • Cisapride Cisapride has been shown to potentiate the prokinetic effect of ranitidine at low doses but antagonize it at higher doses.
  • Used to treat gastric and duodenal ulcers, including NSAID-induced ulceration.
  • Used prophylactically to prevent stress ulcers.
  • Adjunct therapy for reversing metabolic alkalosis.
  • Immunomodulation.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Fewer drug interactions than cimetidine Cimetidine.
  • Antacids, digoxin, ketoconazole or metoclopramide Metoclopramide: ranitidine may reduce their absorption or effect.
  • Sucralfate: may reduce the absorption of ranitidine.

with diagnostic tests

  • Little information available.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Koutsoviti-Papadopoulou M, Nikolaidis E, Batzias G C & Kounenis G (2001) Synergistic and antagonistic pharmacodynamic interaction between ranitidine and cisapride: a study on the isolated rabbit intestine. Pharmacol Res 43 (4), 329-334 PubMed.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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