ISSN 2398-2985      

Propofol

6guinea pig

Synonym(s): Rapinovet, Propoflo, Norofol, Procare, PropoClear, Propoflo Plus, Propoflo 28


Introduction

Name

  • Propofol.

Class of drug

  • Ultra short-acting phenolic intravenous anesthetic.

Description

Chemical name

  • 2,6-diisopropylphenol.

Molecular formula

  • C12H18O.

Molecular weight

  • 178.27.

Physical properties

  • The commercially available injection is an white emulsion that also contains soybean oil, glycerol and egg lecithin.
  • PropoClear is available in some countries; it is not white and contains other excipients.

Storage requirements

  • Store at 4-22°C/39.2-71.6°F.
  • Do not refrigerate or freeze.
  • Protect from light.
  • Shake well before use.
  • Do not use if the emulsion has separated.
  • Once a vial is open, the manufacturer recommends discarding the remaining product after 6 h, even if sterile handling conditions are used. When benzyl alcohol is added to the emulsion (Propoflo 28, Propoflo Plus) the shelf-life (after opening) is extended to 28 days. The combination with benzyl alcohol has not properly evaluated in guinea pigs. PropoClear has also a shelf-life after opening of 28 days.

Uses

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Indications

  • Induction of general anesthesia usually excitement-free recovery.
  • Maintenance of general anesthesia with propofol is not recommended as better alternatives are available.
  • Anesthetic, hypnotic, muscle relaxant.
  • Sedative at low doses.

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • Maguire S & Hawk C T (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster and other Rodents. Eds: Suckow M, Stevens K & Wilson R. Academic Press, USA. pp 1193-1229.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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