ISSN 2398-2985      

Prednisolone

6guinea pig

Synonym(s): Prednisolone acetate, Prednisolone sodium succinate, Prednisolone sodium phosphate, Solu-Delta Cortef, PLT, Prednicare, Pred-forte, Prednidale


Introduction

Name

  • Prednisolone.

Class of drug

  • Synthetic glucocorticoid.

Description

Chemical name

  • 11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a] phenanthren-3-one.

Molecular formula

  • C21H28O5.

Molecular weight

  • 360.44.

Physical properties

  • Odorless, white to practically white, crystalline powder.
  • Very slightly soluble in water and slightly soluble in alcohol.
  • The acetate ester is practically insoluble in water and slightly soluble in alcohol.

Storage requirements

  • Tablets: room temperature in well-closed containers.
  • Avoid freezing liquid products.
  • Prednisolone sodium succinate should be stored at room temperature and protected from light. After reconstitution, the product is recommended for immediate use and not stored.

Uses

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Indications

  • Management of allergic and inflammatory conditions.
  • Useful in the treatment of lymphoma in guinea pigs.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Acetazolamide, Amphotericin B or potassium-depleting diuretics, eg frusemide, thiazides
  • Increased risk of hypokalemia.
Insulin
  • May antagonize the effects of insulin.
Phenytoin or phenobarbitone
  • The metabolism of corticosteroids may be enhanced.

with diagnostic tests

  • May increase serum cholesterol and urine glucose levels.
  • May decrease T3 and T4 values.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Maguire S & Hawk C T (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster and other Rodents. Eds: Suckow M, Stevens K & Wilson R. Academic Press, USA, 1193-1229.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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