ISSN 2398-2985      

Oxytetracycline

6guinea pig

Synonym(s): Oxytetracycline HCl, Engemycin, Oxycare, Terramycin, Oxyject, Biocyl, Liquamycin, Medamycin


Introduction

Name

  • Oxytetracycline.

Class of drug

  • Tetracycline antibiotic.

Description

Molecular formula

  • C22H24N2O9.

Molecular weight

  • 460.43.

Physical properties

  • Oxytetracycline: pale yellow to tan, crystalline powder. Very slightly soluble in water and sparingly soluble in alcohol.
  • Oxytetracycline HCl: bitter-tasting, hygroscopic, yellow, crystalline powder. Freely soluble in water and sparingly soluble in alcohol.

Storage requirements

  • Room temperature and protected from light.

Uses

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Indications

  • Inhibits the growth of many gram-positive and gram-negative bacteria, rickettsiae, mycoplasma, spirochetes and other microbes.
  • Useful to treat Chlamydia infections in guinea pigs, although doxycycline may be preferable. Use oxytetracycline if oral doxycycline produces GI upset.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Penicillins
  • The bactericidal action of the penicillins may be inhibited by oxytetracycline.
Drugs decreasing absorption by binding to tetracycline
  • Antacids containing divalent or trivalent cations (Mg, Ca, Al).
  • Iron.
  • Sodium bicarbonate Sodium bicarbonate.
Digoxin Digoxin
  • The availability may be increased by tetracyclines for months after their discontinuation leading to digoxin toxicity.
Anticoagulants
  • Plasma prothrombin activity may be reduced by tetracyclines and therefore patients on anticoagulant therapy may need a dose adjustment.
Methoxyflurane
  • Tetracyclines may increase the nephrotoxic effects.
Theophyllines
  • The GI effects of tetracyclines may be increased.

with diagnostic tests

  • Oxytetracycline can cause false-positive urine glucose results with some tests.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Maguire S & Hawk C T (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster and other Rodents. Eds: Suckow M, Stevens K, Wilson R. Academic Press, USA. pp 1193-1229.
  • Flecknell P A (1996) Laboratory Animal Anesthesia. 2nd edn. Academic Press, UK.
  • Burgmann P & Percy D H (1993) Antimicrobial Drug Use in Rodents and Rabbits. In: Antimicrobial Therapy in Veterinary Medicine. 2nd edn. Eds: Prescott J F & Baggot J D. Iowa State University Press. pp 524-541.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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