ISSN 2398-2985      

Midazolam

6guinea pig

Synonym(s): Midazolam HCl, Dormicum, Versed, Hypnovel


Introduction

Name

  • Midazolam.

Class of drug

  • Short-acting benzodiazepine.

Description

Chemical name

  • 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride.

Molecular formula

  • Cl8H13ClFN3.

Molecular weight

  • 325.77.

Physical properties

  • White to light yellow crystalline powder.
  • Soluble in water at 10 mg/mL.

Storage requirements

  • Room temperature and protected from light.
  • The injectable form can be frozen (at least for 3 days).

Uses

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Indications

  • Pre-operative sedative agent.
  • Unreliable sedation on its own, although it will sedate depressed animals.
  • Emergency control of seizures Seizures.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Antihistamines, barbiturates, opioid analgesics, or other central nervous system depressants
  • Concurrent use may enhance the sedative effect.
Opioid analgesics, eg pethidine
  • May increase the hypnotic and hypotensive effects of midazolam.
  • Midazolam has very few hypotensive effects.
  • Midazolam has good cardiovascular stability.
Inhalational anesthetics
  • Decrease the dosages required.
Erythromycin
  • Inhibits the metabolism of midazolam.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Schmitz S, Tacke S, Guth B et al (2016) Comparison of physiological parameters and anaesthesia specific observations during isoflurane, ketamine-xylazine or medetomidine-midazolam-fentanyl anaesthesia in male guinea pigs. PLOS ONE 11 (9), e0161258 PubMed.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Maguire S & Hawk C T (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster, and other Rodents. Eds: Suckow M, Stevens K, Wilson R. Academic Press, USA. pp 1193-1229.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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