ISSN 2398-2985      

Medetomidine

6guinea pig

Synonym(s): Medetomidine HCl, Domitor, Domtor, Zalopine, Dorbene, Dormilan, Medetor, Sedastart, Sedator, Sededorm


Introduction

Name

  • Medetomidine.

Class of drug

  • Alpha-2 adrenergic agonist.

Description

Chemical name

  • (RS)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole.

Molecular formula

  • Cl3H16N2.

Molecular weight

  • 200.28.

Physical properties

  • White or almost white crystalline substance.
  • It is soluble in water.

Storage requirements

  • Room temperature and protected from freezing.

Uses

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Indications

  • To provide sedation and analgesia.
  • Good visceral analgesia.
  • Has very potent anesthetic-sparing properties when used as a premedicant.
  • It counteracts muscle rigidity associated with 'dissociative anesthesia' (ketamine Ketamine).
  • It may be used in conjunction with acepromazine Acepromazine maleate, midazolam Midazolam and opioids Morphine to improve the effect of chemical restraint.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Do not use in patients receiving sympathomimetic amines or drugs that depress the cardiovascular system, eg propofol.
  • When used for premedication, medetomidine will significantly reduce the dose of all other anesthetic agents.

with diagnostic tests

  • Causes a transient increase in blood glucose, so affects blood glucose determinations.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Schmitz S, Tacke S, Guth B et al (2016) Comparison of physiological parameters and anaesthesia specific observations during isoflurane, ketamine-xylazine or medetomidine-midazolam-fentanyl anaesthesia in male guinea pigs. PLOS ONE 11 (9), e0161258 PubMed.

Other sources of information

  • ​Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • Hawkins M G & Pascoe P J (2012) Anesthesia, Aalgesia and Sedation of Small Mammals. In: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E & Carpenter J W. Elsevier, USA. pp 429-451.
  • Maguire S & Hawk C T (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster, and other Rodents. Eds: Suckow M, Stevens K & Wilson R. Academic Press, USA. pp 1193-1229.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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