ISSN 2398-2985      

Ketamine

6guinea pig

Synonym(s): Ketamine HCl, Ketaset, Vetalar, Narketan, Ketaflo, Ketaject, Vetamine, Ketaved, VetaKet


Introduction

Name

  • Ketamine.

Class of drug

  • Injectable general anesthetic.
  • Cyclohexanone derivative.
  • N-methyl-D-aspartate (NMDA) receptor antagonist.

Description

Chemical name

  • (+/-)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone.

Molecular formula

  • C13H16ClNO.

Molecular weight

  • 237.73.

Physical properties

  • White crystalline powder.

Storage requirements

  • In a locked cabinet.
  • <25%.
  • Protect from light.

Uses

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Indications

  • A dissociative anesthetic/analgesic used to provide restraint or dissociative anesthesia.
  • Dissociative anesthesia is associated with mild stimulation of cardiac output and blood pressure, modest respiratory depression and preservation of cranial nerve reflexes.

Eyes remain open during anesthesia, thus a bland ophthalmic lubricant should be used.

  • Schedule 4 drug.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Hawkins M G & Pascoe P J (2012) Anesthesia, Analgesia and Sedation of Small Mammals.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.In: Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E, Carpenter J W. Elsevier, USA. pp 429-451.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • •Maguire S & Hawk C T (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster and other Rodents. Eds: Suckow M, Stevens K, Wilson R. Academic Press, United States. pp 1193-1229.
  • Flecknell P (1996) Laboratory Animal Anaesthesia. 2nd edn. Academic Press.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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