ISSN 2398-2985      

Hydromorphone

6guinea pig

Introduction

Name

  • Hydromorphone hydrochloride.

Class of drug

  • Scheduled Class II opioid (narcotic).
  • Controlled substance.

Description

Molecular formula

  • 4,5±-epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride.

Molecular weight

  • 321.80.

Physical properties

  • White powder.
  • Freely soluble in water.
  • Semi-synthetic phenanthrene alkaloid of opium.

Storage requirements

  • Store at room temperature (15-30°C/59-86°F).
  • Protect from light.
  • A slight yellowish tint to the solution may occur but does not indicate loss of potency.
  • The injection remains stable for at least 24 h when mixed with commonly used IV fluids if protected from light.

Uses

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Indications

  • Use as an opioid analgesic Anesthetics, analgesics and sedatives quick reference guide.
  • A cost-effective alternative to oxymorphone.
  • Can be used pre-emptively for elective surgical procedures.
  • Can be used to relieve pain from trauma.
  • Has also been used to provide longer-term pain relief, eg that caused by osteosarcoma.
  • Hydromorphone is more effective at relieving continuous, dull pain versus sharp, intermittent pain.
  • Cough suppressant at low doses.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Can cause profound sedation when combined with acepromazine, alpha2-agonists (xylazine Xylazine, medetomidine Medetomidine) and benzodiazepines.
  • Hydromorphone may reduce the induction dose of injectable anesthetic agents and lower the dose of inhalant agents required for maintenance of anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Ambros B, Knych H K & Sadar M J (2020) Pharmacokinetics of hydromorphone hydrochloride after intravenous and intramuscular administration in guinea pigs (Cavia porcellus). Am J Vet Res 81 (4), pp 361-366 PubMed.
  • Myers D & Jung R A (2009) HydromorphoneJ Exotic Pet Med 18 (1), 71-73.

Other sources of information

  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.
  • The NOAH Compendium. Datasheets of Licensed Veterinary Medicines. Website: www.noahcompendium.co.uk.
  • US Food & Drug Administration (FDA). Questions and Answers on FDA's Adverse Event Reporting System (FAERS). Website: www.fda.gov.
  • Veterinary Medicines Directorate. Adverse Reaction Reporting. Website: www.vmd.defra.gov.uk.

Organisation(s)

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