ISSN 2398-2985      

Hydralazine

6guinea pig

Synonym(s): Hydralazine HCl, Apresoline, Apressinum, Apresolin, Cesoline


Introduction

Name

  • Hydralazine.

Class of drug

  • Peripheral vasodilator.

Description

Chemical name

  • 1(2H)-phthalazinone hydrazone.

Molecular formula

  • C8H8N4.

Molecular weight

  • 160.17.

Physical properties

  • Odorless, white to off-white crystalline powder.
  • One gram is soluble in approximately 25 mL of water and 500 mL of alcohol.

Storage requirements

  • Tablets should be stored in tight, light resistant containers at room temperature.
  • Injectable: room temperature.
  • Avoid refrigeration or freezing.

Uses

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Indications

  • In patients with congestive heart failure, hydralazine significantly increases cardiac output and decreases systemic vascular resistance. Used particularly when enalapril is not effective in clinical improving patients with mitral insufficiency.
  • When treating hypertensive patients (without congestive heart failure) there will be increases of heart rate, cardiac output and stroke volume.
  • Parenteral administration can cause respiratory stimulation.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Drugs enhancing the hypotensive effects of hydralazine
  • ACE inhibitors, eg enapril.
  • Anesthetics.
  • Beta-blockers, eg propranolol.
  • Calcium channel blockers, eg diltiazem, verapamil.
  • Corticosteroids.
  • Diuretics.
  • NSAIDs.
Sympathomimetics, eg phenylpropanolamine
  • May cause an additive tachycardia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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