ISSN 2398-2985      

Glycopyrrolate

6guinea pig

Synonym(s): Glycopyrrolate bromide, Glycopyrronium bromide, Robinul, Glycostigmin, Acpan, Gastrodyn


Introduction

Name

  • Glycopyrrolate.

Class of drug

  • Antimuscarinic agent.

Description

Chemical name

  • 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide.

Molecular formula

  • C19H28BrNO3.

Molecular weight

  • 398.33.

Physical properties

  • Bitter tasting, practically odorless, white, crystalline powder.
  • •One gram is soluble in 20 mL of water and 30 mL of alcohol.

Storage requirements

  • Store at room temperature.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • Its use as a pre-anesthetic drug to reduce oral and bronchial secretions in no longer recommended in guinea pigs. Use only when there is an indication that excessive secretion may produce a problem.
  • In conjunction with long-acting anticholinesterase drugs, eg neostigmine, pyridostigmine during antagonism of neuromuscular block.
  • Pupil dilation in uveitis.
  • Treatment of bradycardia.

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

Alkaline drugs, eg barbiturates
  • When mixed a precipitate may form.
Antihistamines, benzodiazepines, prolonged corticosteroid use (may increase intraocular pressure), pethidine, phenothiazines, procainamide and quinidine
  • The adverse effects of antimuscarinics may be increased.
Nitrofurantoin, sympathomimetics and thiazide diuretics
  • Antimuscarinics may enhance the action.
Metoclopramide

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Maguire S, Hawk CT (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster, and other Rodents. Eds: Suckow M, Stevens K, Wilson R. Academic Press, USA. pp 1193-1229.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code