ISSN 2398-2985      

Enrofloxacin

6guinea pig

Introduction

Name

  • Enrofloxacin.

Class of drug

  • Fluoroquinolone antibiotic.

Description

Molecular formula

  • C19H22FN3O3.

Molecular weight

  • 359.401 g/mol.

Storage requirements

  • Protect from direct sunlight.

Uses

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Indications

  • Pasteurellosis.
  • Gram-negative infections: Pseudomonas spp, Klebsiella spp, Escherichia coli, Proteus spp and Salmonella spp.
  • Other infections: Staphylococcus spp, Pasturella spp and Mycobacteria spp.
  • Enrofloxacin is effective against many beta-lactamase producing bacteria.
  • The fluoroquinolones are highly lipophilic drugs which attain high concentrations within the cells of many tissues and are particularly effective in the management of soft tissue, urogenital (including prostatic) and skin infections.
    Not effective against anaerobic infections

Administration

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Precautions

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Interactions

with other drugs

Adsorbents and antacids containing cations (Mg, Al)
  • May bind to enrofloxacin and prevent its absorption.

Sucralfate and zinc salts

Probenecid/Cisapride

  • Blocks the tubular secretion of enrofloxacin and may increase its blood level and half-life.

NSAIDs

  • In man concurrent use of enrofloxacin and NSAIDs potentiates adverse CNS effects in epileptic patients.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Oglesbee B L (2011) Guinea pigs. In: Blackwell's Five Minute Veterinary Consult: Small Mammal. 2nd edn. Ames, Iowa: Wiley Blackwell. pp 226-341.
  • Keeble E & Meredith A (2009) BSAVA Manual of Rodents and Ferrets. BSAVA.
  • Bregante M A et al (1999) Comparative pharmacokinetics of enrofloxacin in mice, rats, rabbits, sheep, and cows. Am J Vet Res 60 (9), 1111-1116.

Other sources of information

  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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