ISSN 2398-2985      

Diphenhydramine

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Synonym(s): Diphenydramine HCl, Benadryl, Nytol, Dreemon


Introduction

Name

  • Diphenhydramine.

Class of drug

  • Ethanolamine antihistamine.

Description

Chemical name

  • 2-diphenylmethoxy-N,N-dimethylethylethanamine.

Molecular formula

  • C17H21NO.

Molecular weight

  • 291.82.

Physical properties

  • Odorless, white crystalline powder.
  • Slowly darkens with light exposure.
  • Bitter tasting.
  • 1 g is soluble in 1 mL of water and 2 mL of alcohol.

Storage requirements

  • Room temperature.
  • Injectable solution should not be frozen.
  • Oral formulations should be kept in well-closed, tight containers.

Uses

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Indications

  • Used primarily for its antihistamine effects (prevention of motion sickness, cough suppressant, sedative, antiemetic, reduction of pruritus).

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • CNS depressant drugs.
  • Antihistamines may partially counteract the effects of heparin or warfarin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Hofmeister E H & Egger C M (2005) Evaluation of diphenhydramine as a sedative for dogs. JAVMA 226 (7), 1092-1904.
  • Scott D W & Miller W H Jr (1993) Nonsteroidal anti-inflammatory agents in the management of canine allergic pruritus. J S Afr Vet Assoc 64 (1), 52-56.

Other sources of information

  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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