ISSN 2398-2985      

Ciprofloxacin

6guinea pig

Synonym(s): Ciprofloxacin hydrochloride


Introduction

Name

  • Ciprofloxacin.

Class of drug

  • Fluoroquinolone antibiotic.

Description

Chemical name

  • 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid.

Molecular formula

  • C17H18FN3O3.

Molecular weight

  • 331.4.

Physical properties

  • Faintly yellowish to light yellow crystalline powder.
  • Slightly soluble in water.

Storage requirements

  • Oral formulation: store at room temperature and avoid UV exposure.
  • Injectable formulation: store at room temperature, avoid UV exposure and do not freeze.

Uses

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Indications

  • Many gram-negative and gram-positive bacterial and mycoplasmal infections.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • The binding of ciprofloxacin to serum proteins is 20-40% which is not likely to be high enough to cause significant protein binding interactions with other drugs.
  • Probenecid increases serum concentrations of ciprofloxacin.
  • Concurrent administration of antacids containing magnesium hydroxide or aluminum hydroxide may reduce the bioavailability of ciprofloxacin by as much as 90%.
  • Sucralfate inhibits absorption of ciprofloxacin; separate doses of these drugs by at least 2 h.
  • Concomitant administration with tizanidine is contraindicated.
  • Concomitant administration with theophylline is contraindicated.

with diagnostic tests

  • Crystals of ciprofloxacin have been observed in the urine of laboratory animals, which is usually alkaline.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Kapusuz Z, Erol K, Alpay H C et al (2010) The effect of topical ciprofloxacin and steroid-containing ear drops for chronic suppurative otitis media on the internal ear. Europe Archives ORL 267 (1), 35-41 PubMed.
  • Weiss S, Kobiler D, Levy H et al (2011) Antibiotics cure anthrax in animal models. Antimicrob Agents Chemo 55 (4), 1533-1542 PubMed.

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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