ISSN 2398-2985      

Calcium gluconate

6guinea pig

Synonym(s): Calcium salts


Introduction

Name

  • Calcium gluconate.

Class of drug

  • Mineral.

Description

Chemical name

  • D-gluconic acid calcium salt (2:1).

Molecular formula

  • C12H22CaO14.

Molecular weight

  • 430.06.

Physical properties

  • Sparingly soluble in water.

Storage requirements

  • Room temperature.
  • Injectable calcium gluconate should not be frozen.

Uses

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Indications

  • To treat conditions arising from calcium deficiency.
  • Hypocalcemia.
  • Uterine inertia Dystocia.
  • Management of hyperkalemic cardiotoxicity associated with urinary obstruction. Calcium gluconate rapidly corrects arrhythmias but has a short duration of effect (5-10 min).
  • Calcium requirements for growing guinea pigs are 8 g/kg of food (=0.8%) when levels of phosphorus and vitamin D are appropriate. Appropriate levels of phosphorus in guinea pig are half of those for calcium, eg about 0.4%.
  • Adult guinea pigs are likely to have lower requirements.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Do not add calcium salts to IV solutions containing bicarbonate, carbonate, phosphate, sulfate or tartrate salts.
  • Arrythmias may develop if IV calcium is given to patients on digoxin Digoxin therapy.
  • Antagonizes the effects of verapamil.
  • Calcium gluconate cannot be used with metoclopramide Metoclopramide.
  • Cannot be used with propofol Propofol, amphotericin B Amphotericin B and methylprednisolone Methylprednisolone sodium succinate.
  • Concurrent use with thiazide diuretics may facilitate hypercalcemia.
  • Oral administration can reduce the amount of tetracyclines absorbed from the GI tract.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, UK.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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