ISSN 2398-2985      

Buprenorphine

6guinea pig

Introduction

Name

  • Buprenorphine.

Class of drug

  • Long-acting partial opioid antagonist-agonist.

Description

Chemical name

  • (2-5R,6R,7R,14S)-9alpha-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutan-2-ol.

Molecular formula

  • C29H41NO4.

Molecular weight

  • 467.64.

Storage requirements

  • Protect from light.

Uses

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Indications

  • May be mixed with acepromazine Acepromazine maleate to produce neuroleptanalgesia for minor procedures or pre-operative medication.
  • Used to relieve moderate pain.
  • Sedative and euphoric effects less marked than those produced by morphine.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Opioid analgesics
  • Do not use in conjunction with these as it is a partial agonist and will antagonize the effects of full agonists (morphine Morphine, pethidine).
  • May potentiate sedative and ventilatory depressant effects of other CNS depressants.
  • Can be used to reverse sedative effects of fentanyl/fluanisone Fentanyl while maintaining analgesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Sadar M J, Knych H, Drazenovich T et al (2014) Pharmacokinetics of buprenorphine in the guinea pig (Cavia porcellus): intravenous and oral transmucosal administration. In: Proc Assoc Exotic Mammal Vet Conf. Orlando, FL. pp 19-24.

Other sources of information

  • Ramsey I (2014) BSAVASmall Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • Carpenter J W (2005) Ed Exotic Animal Formulary. 3rd edn. St. Louis: Elsevier Saunders.
  • Hillyer E V & Quesenberry K E (1997) Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. 1st edn. New York: W.B. Saunders. pp 24.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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