ISSN 2398-2985      

Bupivacaine

6guinea pig
Contributor(s):

Vetstream Ltd

David Vella


Introduction

Name

  • Bupivacaine.

Class of drug

  • Local anesthetic.

Description

Chemical name

  • 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide.

Molecular formula

  • C18H28N2O.

Molecular weight

  • 288.435 g/mol.

Physical properties

  • Clear, sterile solution.

Storage requirements

  • <25°C/77°F.

Uses

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Indications

  • Used predominantly as a local anesthetic.
  • Has a longer duration of action than most other local anesthetic agents.
  • Effects not seen for up to 30 min but usually within 15-20 min.
  • Duration of action 4-7 h in most rodents.

Administration

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Precautions

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Interactions

with other drugs

Propranolol
  • May increase bupivicaine effects if administered concurrently.
Other local anesthetics
  • Dose of bupivacaine should be reduced when used in combination with other local anesthetics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Badgwell J M et al (1990) Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics. Anesthesiology 73 (2), 297-303 PubMed.

Other sources of information

  • Ramsey I et al (2011) Bupivacaine. In: BSAVA Small Animal Formulary. 7th edn. BSAVA, UK.
  • Gaertner D J et al (2008) Anesthesia and Analgesia for Laboratory Rodents. In: Anesthesia and Analgesia in Laboratory Animals. 2nd edn. Elsevier. pp 239-298.
  • Lichtenberger M & Ko J (2007) Anaesthesia and Analgesia for Small Mammals and Birds. Vet Clin North Am Exotic Anim Pract 10 (2), 293-315.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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