ISSN 2398-2985      

Amikacin

6guinea pig
Contributor(s):

Vetstream Ltd

Mark Naguib


Introduction

Name

  • Amikacin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • Pseudomonas aeruginosa infections.
  • Gentamicin-resistant infections Gentamicin.
  • Probable gentamicin-resistant, gram-negative infections.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Avoid the concurrent use of other nephrotoxic, ototoxic or neurotoxic agents, eg amphotericin B Amphotericin B, cisplatin, furosemide Furosemide, methoxyflurane. Increase monitoring and adjust dosages when these drugs must be used with amikacin.
  • Aminoglycosides may be inactivated by beta-lactam antibiotics, eg penicillins, cephalosporins or heparin when mixed in vitro. This may present a problemin vivoin patients who have substantially diminished renal function.
  • The effect of non-depolarizing muscle relaxants, eg atracurium, pancuronium, tubocuramine, vecuronium, may be enhanced by aminoglycosides.
  • Synergism may occur when aminoglycosides are used with penicillins or cephalosporins (Streptococcus faecalis) or with ticarcillin (Pseudomonas aeruginosa).

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Legendre L (2016) Anatomy and disorders of the oral cavity of guinea pigs. Veterinary Clinics of North America: Exotic Animal Practice. 19 (3), 825-842 PubMed.
  • McClure J T & Rosin E (1998) Comparison of amikacin dosing regimens in neutropenic guinea pigs with Escherichia coli infection. American journal of veterinary research. 59 (6) 750-755 PubMed.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary 9th edition: Part B - Exotic Pets. BSAVA, UK. pp 195.
  • Bishop Y (1998) Ed The Veterinary Formulary. 4th edn. British Veterinary Association and Royal Pharmaceutical Society.
  • Carpenter (2013) Exotic Animal Formulary. 4th edn. Greystone Publications.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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